Cialis is the hottest PDE-5 (phosphodiasterase-5) inhibitors in the market today for the patients of erectile dysfunction. It’s sales have crossed those of the earlier market leader Viagra and today Cialis . is the number one brand in key markets such as France. What really makes Cialis the most preferred erectile dysfunction drug today? Before we answer that firstly let is understand, what is erectile dysfunction? Erectile dysfunction is defined as the inability to ensure or sustain an erection for satisfactory sexual intercourse. It occurs in 50% of men over the age of 40. If affects 180 million men all over the world. What is most shocking is that hardly 5% of them seek treatment.
How does erectile dysfunction occur? There are basically two reasons for erectile dysfunction. Firstly erectile dysfunction can happen because of poorly functioning blood vessels. The blood vessels that supply blood to the penis do not dilate properly as they are clogged with excess fat or other reasons. This occurs in 90% of the people with erectile dysfunction. Secondly due to psychological reasons such as stress, depression, etc erectile dysfunction can also happen. This happens in 10% of the people with erectile dysfunction. Erectile dysfunction leads to considerable loss of potency and further on leads to loss of self esteem.
Cialis was developed by the biotech company ICOS and marketed all over the world by world renowned pharmaceutical company Lilly. Cialis contains Tadalafil, the second generation PDE-5 inhibitor. It effectively inhibits the enzyme Phosphodiasterase-5, which is responsible for the degradation of the enzyme cGMP (cyclic guanosine monophosphate) which through a series of reactions is responsible for the production of nitric oxide. Nitric oxide is a powerful vasodilator, which causes dilatation of the blood vessels that supply blood to the penis. The penis fills with blood and we have an erection due to hydraulic pressure.
In a review article by Dr. Porst H. published in the journal - Urological Practice, the benefits of Cialis were clinically documented. In the European daily-dosing trial, the efficacy rates were up to 93% for successful sexual intercourses with completion in the 50-mg dose in patients with mild to moderate erectile dysfunction (ED). In two different dose-ranging studies with 2-25 mg taken as needed efficacy rates of up to 88% improvement in erections and up to 73% successful sexual intercourses with completion were achieved.
In a placebo-controlled, fixed-dose (10- and 20-mg) trial in diabetic patients on Cialis, improved erections of 56% and 64% were reported compared with 25% after placebo. Clearly, when it comes to diabetic patients, there is a definite advantage with Cialis. However the US-FDA has warned that diabetics using Cialis must be careful as it is known to cause vision related disturbances.
Drug-related adverse effects are seen, with headache in up to 23% of patients (placebo, up to 17%), dyspepsia in up to 11% (placebo, up to 7%), back pain in up to 4.7% (placebo, 0%), and myalgia in up to 4.1% (placebo, up to 2.4%), were mostly mild to moderate. Neither drug-related serious cardiovascular adverse events nor color vision disturbances
Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using nitrates within this timeframe may increase the risk of life-threatening hypotension.
The long half-life (>17 h), with a comfortably long window of opportunity, releases couples from the need to schedule sexual activities (as they would plan their daily schedule) and therefore provides the highest amount of spontaneity for sexual activities. On tablet of Cialis is sufficient for more than 36 hours. Sex, thus become a fun activity that adds value to the relationship.
the tablets of Cialis are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of Viagra. This clearly shows the potency of Cialis.
There is a lot of competition between sites that sell Cialis. This competition drives down the prices. One should be very careful, while if one wants to buy Cialis. A very popular website where cheap Cialis is available is Cialis Online. At this site you will get attractive bargains for Cialis – even as much as 50% on the marked price. If you are a man with erectile dysfunction or a spouse of the same - ensure potency is preserved with Cialis.
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